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Concurrent mutations, in genes such as CDKN2B (Montrer CDKN2B Protéines) or RB1, were associated with worse clinical outcome in lung adenocarcinoma patients with EGFR (Montrer EGFR Protéines) active mutations.
Mutational screening of germline RB1 gene in Vietnamese patients with retinoblastoma reveals three novel mutations.
Analyses with phospho-defective and phospho-mimetic mutants of FoxM1b (Montrer FOXM1 Protéines) identified a critical role of the Plk1 phosphorylation sites in regulating the binding of FoxM1b (Montrer FOXM1 Protéines) to Rb and DNMT3b (Montrer DNMT3B Protéines).
The accumulation of sequence variations in RB1 gene might influence Greek patients' susceptibility towards the progression of cervical neoplasia.
vitiligo (Montrer MITF Protéines) lesions exhibited dysregulated SUMOylation and deSUMOylation in keratinocytes, dysregulation of the cell cycle progression was observed in SUMO1 (Montrer SUMO1 Protéines) knockdown HaCaT cells and the deSUMOylation of Rb in keratinocytes may serve an important role in the development of vitiligo (Montrer MITF Protéines).
The Rb1 tumor suppressor gene modifies telomeric chromatin architecture by regulating TERRA (Montrer DMRT2 Protéines) expression.
These findings demonstrate that developmental stage-specific as well as species- and cell type-specific features sensitize to RB1 inactivation and reveal the human cone precursors' capacity to model retinoblastoma initiation, proliferation, premalignant arrest, and tumor growth.
Low pRB expression is associated with mouth Cancer.
Control of the Restriction Point by Rb and p21 (Montrer CDKN1A Protéines).
PPM1B (Montrer PPM1B Protéines) plays a negative role in the activation of the p38 (Montrer CRK Protéines)-RB1-E2F1 (Montrer E2F1 Protéines) pathway and that targeting PPM1B (Montrer PPM1B Protéines) could be useful in certain types of cancer by stimulating chemotherapy-induced cell death.
Thus, Lin37 (Montrer LIN37 Protéines) is an essential component of DREAM complex that cooperates with Rb to induce quiescence.
Results show that ablation of the three members of the retinoblastoma family (RB1, p107 (Montrer RBL1 Protéines) and p130) which targets a variety of adult lung epithelial cells, leads to spontaneous velopment of tumorlets, benign precancerous neuroendocrine (NE) lesions that do not progress to malignant tumors. Data imply the requirement of other oncogenic signaling pathways for full transformation in NE lung lesions mutant for the Rb family.
NFIB (Montrer NFIB Protéines) overexpression interacts with Rb/p53 (Montrer TP53 Protéines) deletion to promote small cell lung cancer in a mouse model
studies demonstrate that pRb (Montrer PGR Protéines) loss in the Tie2 (Montrer TEK Protéines)-lineage that includes aortic valve interstitial cells is sufficient to cause age-dependent aortic valve dysfunction
Cytokeratin-19 (CK-19 (Montrer KRT19 Protéines))+ specific deletion of tumor suppressors p53 (Montrer TP53 Protéines) and Retinoblastoma (Rb) indicated that carcinomas at the injury site originates from cholangiocytes or liver progenitor cells.
Rb selectively inhibits innate IFN-beta (Montrer IFNB1 Protéines) production by enhancing deacetylation of Ifnb1 (Montrer IFNB1 Protéines) promoter, exhibiting a previous unknown non-classical role in innate immunity, which also suggests a role of Rb in the regulation of type I IFN production in inflammatory or autoimmune diseases.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
Findings indicate that inactivation of the Rb family proteins (Rb, p107 (Montrer RBL1 Protéines), and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 (Montrer SOCS3 Protéines) protein (Socs3 (Montrer SOCS3 Protéines)) expression in triple knockout (TKO (Montrer MRPS12 Protéines)) HSCs.
data indicate that the Rb1-E2F1 (Montrer E2F1 Protéines)-caspase (Montrer CASP3 Protéines) axis is crucial for protecting immature T cells from apoptosis during early T lymphocyte maturation.
Our results indicate that Rb-Raf-1 (Montrer RAF1 Protéines) interaction plays an important role in spontaneous hair cell regeneration in zebrafish
our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.
Zebrafish usp39 (Montrer USP37 Protéines) regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 (Montrer E2F4 Protéines) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
retinoblastoma suspectibility protein
, retinoblastoma-associated protein
, retinoblastoma-like protein 1
, Retinoblastoma 1 (including osteosarcoma)
, retinoblastoma 1 (including osteosarcoma)
, retinoblastoma protein
, retinoblastoma, susceptibility
, Retinoblastoma-associated protein
, retinoblastoma 1
, retinoblastoma-associated protein-like