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Results demonstrate the existence of crosstalk between beta-catenin signaling and HGS in two different types of cancer (hepatoblastoma and colorectal).
ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM (Montrer STAM Protéines)) and the complex formation with STAM (Montrer STAM Protéines) promotes its endosomal dissociation.
we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT).
the role for tumoral c-Met expression or sMet/HGF (Montrer HGF Protéines) levels as upfront selection criterion or predictive biomarkers deserve further study in this emerging area of therapeutic focus in RCC (Montrer XRCC1 Protéines)
Hrs tyrosine phosphorylation detected upon EGF (Montrer EGF Protéines)-stimulation.
Hrs inhibits HIV-1 production by inhibiting citron kinase (Montrer CIT Protéines)-mediated exocytosis.
ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin (Montrer BST2 Protéines) down-regulation.
Plasma hepatocyte growth factor (Montrer HGF Protéines) is associated with periampullary cancer.
hSpry2 binds to the endocytic regulatory protein, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and blocks intracellular signal propagation.
The HRS domain required for merlin (Montrer NF2 Protéines) binding is narrowed to a region (residues 470-497) containing the predicted coiled-coil domain whereas the major domain responsible for HRS growth suppression is distinct (residues 498-550).
structure of a complex of Hrs-UIM and ubiquitin at 1.7-A resolution [ubiquitin]
Findings find that Hrs is indispensable for the autophagic clearance of neurodegeneration-related proteins and for the survival of hippocampal neurons in mammals. In particular, the work provides the novel insight that the loss of Hrs results in insufficient autophagic clearance and enhanced ER stress, thereby triggering JNK (Montrer MAPK8 Protéines) activation and subsequent apoptotic and necroptotic neuronal cell death.
HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function.
Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.
A new mechanism to modify BMP signaling by Hgs during early mouse development.
Hrs is a master molecule that controls in part the degradation of STAM1 (Montrer STAM Protéines) and the accumulation of ubiquitinated proteins
Data suggest that Hrs regulates the KGFR (Montrer FGFR2 Protéines) degradative pathway, but not its juxtanuclear recycling transport, and that Hrs recruitment to the receptor, but not its ligand-induced phosphorylation, could be required for its function.
Nedd4-2 (Montrer NEDD4L Protéines) induces binding of ENaC (Montrer SCNN1A Protéines) to Hrs, which mediates the sorting decision between ENaC (Montrer SCNN1A Protéines) degradation and recycling.
Peptidergic versus nonpeptidergic specification depends on a balance between HGF (Montrer HGF Protéines)-Met signaling and Runx1 (Montrer RUNX1 Protéines) extinction/maintenance in primary nociceptive neurons.
Src (Montrer SRC Protéines) phosphorylates Hrs in vitro & in vivo. Hrs is phosphorylated in Src (Montrer SRC Protéines)-, Yes- & Fyn (Montrer FYN Protéines)-negative cells. 10-20% is phosphorylated after EGF (Montrer EGF Protéines) stimulation at multiple tyrosines in different parts of Hrs by several kinases downstream of the EGF receptor (Montrer EGFR Protéines).
These results reveal that ESCRT-0 (ESCRT-0 components stam (Montrer STAM Protéines) and hrs)mutants inhibit EGFR (Montrer EGFR Protéines) signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
Hrs is dispensable for cytokinesis. Finally, it was found that although Drosophila Hrs does not localize at acrosome, the other endosomal markers--Rab4, Rab7, and Rab11--are detected at the organelle.
Drosophila epithelia lacking Hrs and Stam (Montrer STAM Protéines), accumulate Notch (Montrer NOTCH1 Protéines) and Dome in endosomes, maintain normal apico-basal polarity and proliferation control and do not show ectopic Notch (Montrer NOTCH1 Protéines) signaling activation.
Hrs mediates Smo trafficking in the late endosome by not only promoting Smo ubiquitination but also blocking Smo phosphorylation.
these data support a model in which Ubpy (Montrer USP8 Protéines) plays a dual role in both cargo deubiquitylation and the ESCRT-0 subunit Hrs stability during development.
show that the endosomal proteins Myopic (Mop (Montrer OPN4 Protéines)) and Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) are required for the activation of the Toll (Montrer TLR4 Protéines) signaling pathway.
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
human growth factor-regulated tyrosine kinase substrate
, protein pp110
, HGF-regulated tyrosine kinase substrate
, SNAP-25-interacting protein Hrs-2
, hepatocyte growth factor-regulated tyrosine kinase substrate
, hepatocyte growth factor regulated tyrosine kinase
, hepatocyte growth factor regulated tyrosine kinase substrate
, hepatocyte growth-factor-regulated substrate
, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog