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Human Monoclonal Uchl3 Primary Antibody pour ELISA, WB - ABIN534413
Osaka, Wang, Takada, Takizawa, Setsuie, Li, Sato, Nishikawa, Sun, Sakurai, Harada, Hara, Kimura, Chiba, Namikawa, Kiyama, Noda, Aoki, Wada: Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. dans Human molecular genetics 2003
Show all 3 Pubmed References
Human Polyclonal Uchl3 Primary Antibody pour IF (p), IHC (p) - ABIN1387243
Wang, Yu, Hu, Cheng, Li: Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization. dans PLoS ONE 2016
Human Monoclonal Uchl3 Primary Antibody pour ELISA, WB - ABIN563334
Nogueira da Costa, Mijal, Keen, Findlay, Wild: Proteomic analysis of the effects of the immunomodulatory mycotoxin deoxynivalenol. dans Proteomics 2011
UCH-L3 might play a role in epithelial ovarian cancer pathogenesis and progression
Depletion of UCHL3 increases TDP1 ubiquitylation and turnover rate and sensitizes cells to TOP1 poisons. Overexpression of UCHL3, but not a catalytically inactive mutant, suppresses TDP1 ubiquitylation and turnover rate.
UCHL3 facilitates cellular viability after DSB induction by antagonizing Ku80 ubiquitylation to enhance Ku80 retention at sites of damage.
The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity.
Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility.
Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis.
UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells.
Data identified of UCHL3 as an essential deubiquitinase in adipogenesis.
impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie
1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases
Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms
Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.
These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 and UCH-L3, respectively, in vivo.
Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3
identification and the sequence-specific assignments for 186 out of the 218 UCH-L3 (230 less 12 prolines) backbone 15N and amide proton resonances
Data suggest that the activity of oocyte UCHL-1 and -3 contributes to oocyte maturation by regulating the oocyte cortex and meiotic spindle.
subfertile Uchl1(gad-/-) mutant mice showed an intriguing pattern of switched UCH localization, with UCHL3 replacing UCHL1 in the oocyte cortex
Results suggest that Uch-L3 enhances osteoblast differentiation through the stabilization of Smad1 signaling
Polyubiquitinated proteins accumulate in skeletal muscle as well as in mouse embryonic fibroblasts derived from Uchl3-deficient mice.
Results suggest that UCH-L3 promotes adipogenesis by enhancing insulin signaling in a hydrolase activity-dependent manner.
The role of ubiquitin C-terminal hydrolase (UCH)-L3 in the regulation of AMP-activated protein kinase activity and whole-body energy metabolism are reportedl
UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
Data show that Uchl3 and mitofilin are differentially expressed in the hippocampi of inbred senescence-acclerated mice compared to normally-aging mice.
swine UCHL3, RIT1 and CCND3 genes were differentially expressed in tissues including small intestine, large intestine, liver, muscle, fat, lung, spleen and kidney
The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
ubiquitin carboxyl-terminal hydrolase isozyme L3
, ubiquitin thioesterase L3
, ubiquitin thiolesterase
, ubiquitin carboxyl-terminal hydrolase-6
, ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
, ubiquitin carboxyl-terminal esterase L4