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Human Monoclonal HS6ST1 Primary Antibody pour ELISA, WB - ABIN522851
Lu, Auduong, White, Yue: Up-regulation of heparan sulfate 6-O-sulfation in idiopathic pulmonary fibrosis. dans American journal of respiratory cell and molecular biology 2014
RT-PCR analysis showed that the overall transcriptional activity of the main Heparan Sulfate biosynthesis-involved genes (EXT1 (Montrer EXT1 Anticorps), EXT2 (Montrer EXT2 Anticorps), NDST1 (Montrer NDST1 Anticorps), NDST2 (Montrer NDST2 Anticorps), GLCE (Montrer GLCE Anticorps), HS2ST1 (Montrer HS2ST1 Anticorps), HS3ST1 (Montrer HS3ST1 Anticorps), HS3ST2 (Montrer HS3ST2 Anticorps), HS6ST1, HS6ST2 (Montrer HS6ST2 Anticorps), SULF1 (Montrer SULF1 Anticorps), SULF2 (Montrer SULF2 Anticorps), HPSE (Montrer HPSE Anticorps)) was decreased by 1.5-2-fold in Grade II-III glioma.
HS6ST-1 and HS6ST-2 (Montrer HS6ST2 Anticorps) have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF (Montrer HBEGF Anticorps) signaling and subsequent expression of angiogenic cytokines by cancer cells
Hs6st1 and Hs2st (Montrer HS2ST1 Anticorps) generate conditions conducive to corpus callosum development.
idiopathic hypogonadotrophic hypogonadism--associated HS6ST1 mutations display reduced activity in vitro and in vivo, suggesting that HS6ST1 and the complex modifications of extracellular sugars are critical for normal development
we have characterized HS6ST-2 (Montrer HS6ST2 Anticorps) and HS6ST-1 human isologues, including their chromosomal localizations,HS6STs could also transfer sulphate to N -sulphoglucosamine residues located at the non-reducing terminal of HS with high affinity.
Distinct expression patterns of Sulf1 (Montrer SULF1 Anticorps) and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.
both HS6ST-1 and HS6ST-2 (Montrer HS6ST2 Anticorps) are involved in 6-O-sulfation of heparin and that the proper packaging and storage of tryptase (Montrer TPSAB1 Anticorps)
6OST1 is predominantly transcribed in epithelial and neural-derived tissues during development
Data show that high expression of 6-O-sulfotransferase (6-OST)-1, 2, or 3 resulted in increased 6-O-sulfation of N-sulfated (Montrer SULF1 Anticorps) and N-acetylated glucosamine units, and in altered heparan sulfate domain structure.
Hs2st and/or Hs6st1 expression coincides with Slit expression domains at locations where retinal ganglion cell(RGC) axons make navigation errors in Hs2st-/- and Hs6st1-/- mutants, and Hs6st1-/-RGC axons are less sensitive to Slit2 repulsion.
there is a critical role for HS 6-O sulfation by Hs6st1 in postnatal processes
The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene.
, heparan-sulfate 6-O-sulfotransferase 1
, heparan-sulfate 6-sulfotransferase
, Heparan-sulfate 6-O-sulfotransferase 1
, heparan sulfate 6-sulfotransferase
, HS 6-OST-1A
, heparan sulfate 6-O-sulfotransferase 1
, heparan-sulfate 6-O-sulfotransferase 1-A