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RT-PCR analysis showed that the overall transcriptional activity of the main Heparan Sulfate biosynthesis-involved genes (EXT1 (Montrer EXT1 Protéines), EXT2 (Montrer EXT2 Protéines), NDST1 (Montrer NDST1 Protéines), NDST2 (Montrer NDST2 Protéines), GLCE (Montrer GLCE Protéines), HS2ST1 (Montrer HS2ST1 Protéines), HS3ST1 (Montrer HS3ST1 Protéines), HS3ST2 (Montrer HS3ST2 Protéines), HS6ST1, HS6ST2 (Montrer HS6ST2 Protéines), SULF1 (Montrer SULF1 Protéines), SULF2 (Montrer SULF2 Protéines), HPSE (Montrer HPSE Protéines)) was decreased by 1.5-2-fold in Grade II-III glioma.
HS6ST-1 and HS6ST-2 (Montrer HS6ST2 Protéines) have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF (Montrer HBEGF Protéines) signaling and subsequent expression of angiogenic cytokines by cancer cells
Hs6st1 and Hs2st (Montrer HS2ST1 Protéines) generate conditions conducive to corpus callosum development.
idiopathic hypogonadotrophic hypogonadism--associated HS6ST1 mutations display reduced activity in vitro and in vivo, suggesting that HS6ST1 and the complex modifications of extracellular sugars are critical for normal development
we have characterized HS6ST-2 (Montrer HS6ST2 Protéines) and HS6ST-1 human isologues, including their chromosomal localizations,HS6STs could also transfer sulphate to N -sulphoglucosamine residues located at the non-reducing terminal of HS with high affinity.
Distinct expression patterns of Sulf1 (Montrer SULF1 Protéines) and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.
both HS6ST-1 and HS6ST-2 (Montrer HS6ST2 Protéines) are involved in 6-O-sulfation of heparin and that the proper packaging and storage of tryptase (Montrer TPSAB1 Protéines)
6OST1 is predominantly transcribed in epithelial and neural-derived tissues during development
Data show that high expression of 6-O-sulfotransferase (6-OST)-1, 2, or 3 resulted in increased 6-O-sulfation of N-sulfated (Montrer SULF1 Protéines) and N-acetylated glucosamine units, and in altered heparan sulfate domain structure.
Hs2st and/or Hs6st1 expression coincides with Slit expression domains at locations where retinal ganglion cell(RGC) axons make navigation errors in Hs2st-/- and Hs6st1-/- mutants, and Hs6st1-/-RGC axons are less sensitive to Slit2 repulsion.
there is a critical role for HS 6-O sulfation by Hs6st1 in postnatal processes
The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene.
, heparan-sulfate 6-O-sulfotransferase 1
, heparan-sulfate 6-sulfotransferase
, Heparan-sulfate 6-O-sulfotransferase 1
, heparan sulfate 6-sulfotransferase
, HS 6-OST-1A
, heparan sulfate 6-O-sulfotransferase 1
, heparan-sulfate 6-O-sulfotransferase 1-A