MECP2 Protéines

Profil protéine

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Alternative names and synonyms associated with MECP2

• methyl-CpG binding protein 2 (MECP2) anticorps
• methyl CpG binding protein 2 (Mecp2) anticorps
• methyl CpG binding protein 2 (mecp2) anticorps
• methyl-CpG binding protein 2 S homeolog (mecp2.S) anticorps

• 1500041B07Rik anticorps
• AUTSX3 anticorps
• BB130002 anticorps
• D630021H01Rik anticorps
• Mbd5 anticorps
• Afficher tous les alias de synonymes
• MRX16 anticorps
• MRX79 anticorps
• MRXS13 anticorps
• MRXSL anticorps
• PPMX anticorps
• RS anticorps
• RTS anticorps
• RTT anticorps
• WBP10 anticorps
• wu:fk96a04 anticorps
• zgc:111857 anticorps

Protein level used designations for MECP2

meCp-2 protein , methyl-CpG-binding protein 2 , meCP-2 protein , methyl-CpG-binding protein MeCP2