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anti-Mouse (Murine) PARK7 Anticorps:
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Chicken Polyclonal PARK7 Primary Antibody pour ICC, IF - ABIN152611
Jin, Li, Davis, Zhu, Wang, Pan, Zhang: Identification of novel proteins associated with both alpha-synuclein and DJ-1. dans Molecular & cellular proteomics : MCP 2007
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Human Polyclonal PARK7 Primary Antibody pour ELISA, WB - ABIN249806
Ooe, Taira, Iguchi-Ariga, Ariga: Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. dans Toxicological sciences : an official journal of the Society of Toxicology 2005
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Human Polyclonal PARK7 Primary Antibody pour ICC, IF - ABIN151929
Hong, Shi, Chung, Quinn, Peskind, Galasko, Jankovic, Zabetian, Leverenz, Baird, Montine, Hancock, Hwang, Pan, Bradner, Kang, Jensen, Zhang: DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. dans Brain : a journal of neurology 2010
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Human Monoclonal PARK7 Primary Antibody pour ICC, IHC (fro) - ABIN335354
Bonné, Gilbert, Hatzfeld, Chen, Green, van Roy: Defining desmosomal plakophilin-3 interactions. dans The Journal of cell biology 2003
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Zebrafish (Danio rerio) Polyclonal PARK7 Primary Antibody pour WB - ABIN1881625
Bai, Mullett, Garver, Hinkle, Burton: Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons. dans Brain research 2006
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Human Polyclonal PARK7 Primary Antibody pour ELISA, WB - ABIN564912
Morrison, Thompson, Williamson, Cheetham, Robinson: A simple cell based assay to measure Parkin activity. dans Journal of neurochemistry 2011
Human Polyclonal PARK7 Primary Antibody pour WB - ABIN524725
Donadio, Giusti, Cetani, Da Valle, Ciregia, Giannaccini, Pardi, Saponaro, Torregrossa, Basolo, Marcocci, Lucacchini: Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glands. dans Proteome science 2011
Cow (Bovine) Monoclonal PARK7 Primary Antibody pour ICC, IF - ABIN4343700
Wang, Fang, Zhang, Li, Guan, Sun, Xie, Zhong: The positive correlation between DJ-1 and β-catenin expression shows prognostic value for patients with glioma. dans Neuropathology : official journal of the Japanese Society of Neuropathology 2013
Melatonin, added together with MPTP (Montrer PTPN2 Anticorps) or added once MPTP (Montrer PTPN2 Anticorps) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin (Montrer PARK2 Anticorps)/PINK1 (Montrer PINK1 Anticorps)/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
Low DJ-1 expression impairs synaptic vesicle endocytosis and reavailability at nerve terminals.
DJ-1 deficiency causes defects in astrocyte-mediated repair of brain damage.
In cultured neurons and forebrain samples from Dj1(-/-) animals, there was chloride damage and a profound structural remodeling of the mitochondrial respiratory chain.
DJ-1 has a role in glutamate (Montrer GRIN1 Anticorps) uptake into astrocytes by regulating flotillin-1 (Montrer FLOT1 Anticorps) and caveolin-1 (Montrer CAV1 Anticorps) expression
Network analysis reveals DJ-1/LDLR (Montrer LDLR Anticorps) as common host proteins modulating pathogenesis of neurotropic viruses.
Induction of DJ-1 may serve as a novel regulator for hepatocellular carcinoma cell proliferation and HCC (Montrer FAM126A Anticorps) development possibly through enhanced MAPK (Montrer MAPK1 Anticorps) signaling and inflammation.
chaperone-mediated autophagy protects mitochondrial function by degrading nonfunctional PARK7 and maintaining its homeostasis, and dysregulation of this pathway may contribute to the neuronal stress and death in Parkinson disease pathogenesis
Knockdown of DJ-1 attenuates Nurr1 (Montrer NR4A2 Anticorps) activity.
These results demonstrate that DJ-1 KO mice display progressive signs of retinal/RPE (Montrer RPE Anticorps) degeneration in association with higher levels of oxidative stress markers. Collectively this analysis indicates that DJ-1 plays an important role in protecting photoreceptors and RPE (Montrer RPE Anticorps) from oxidative damage during aging
DJ-1 activates autophagy to alleviate cardiac hypertrophy.
DJ-1 promoter polymorphism is associated with male infertility.
The PD-associated L166P mutant, but not wild-type DJ-1, directly binds to and is cleaved by the mitochondrial serine protease Omi (Montrer HTRA2 Anticorps) at both serine residues 3 and 121.
DJ-1 plays a major role in various signaling pathways. Related to its anti-oxidant properties, it mediates cell survival and proliferation by activating the extracellular signal-regulated kinase (ERK1/2) pathway and attenuates cell death signaling by inhibiting apoptosis signal-regulating kinase 1 (ASK1 (Montrer MAP3K5 Anticorps)) activation. [review]
the present study highlighted the involvement of DJ1 in HGrelated EC injury and identified that DJ1 exerts a cellular protective effect in HUVECs exposed to HG induced oxidative stress via activation of the PI3K (Montrer PIK3CA Anticorps)/AkteNOS signaling pathway.
These findings suggest that oxidation-induced ubiquitination and degradation can be a quality control mechanism of oxidized redox-sensitive proteins including Prxs and DJ-1.
study implies that DJ-1 may protect endothelial progenitor cells against Ang II (Montrer AGT Anticorps)-induced dysfunction by activating the PPARgamma (Montrer PPARG Anticorps)/HO-1 (Montrer HMOX1 Anticorps).
Studied serum levels of Parkinson's disease-associated protein 7 (DJ-1) and human epididymis protein 4 (HE4 (Montrer WFDC2 Anticorps)) in endometrial cancer (EC) patients and healthy controls. The median serum concentrations of DJ-1 and HE4 (Montrer WFDC2 Anticorps) were found to be significantly higher in EC patients compared to controls.
Study shows the generation of oxDJ-1 in erythrocytes in early stage, unmedicated parkinson's disease (PD) patients and in non-human primates with PD symptoms. In addition, oxDJ-1 interacts with 20S proteasome (Montrer PSMA5 Anticorps) in the erythrocytes of PD patients. The current findings suggest that oxidative stress is systemically present in PD patients and suggest that an early pathophysiological mechanism operates in PD.
Not only is protein deglycase DJ-1 (DJ-1) linked to familial Parkinson's disease (PD), but it is also associated with the pathogenic mechanisms of sporadic PD and other neurodegenerative disorders where oxidative stress is implicated [Review].
Studies indicate that protein deglycase DJ-1 (DJ-1) plays a critical role in cancer [Review]
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22