HFE2 Kit ELISA

N° du produit ABIN5510628

Détail du produit HFE2 Kit ELISA

Antigène: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Épitope: AA 36-396

Reactivité: Rat

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Hemojuvelin/RGM-C

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: Q36-D396

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Autre désignation: Hfe2 (HFE2 Produits)

Synonymes: HFE2A Kit ELISA, HJV Kit ELISA, JH Kit ELISA, RGMC Kit ELISA, HFE2 Kit ELISA, DKFZp468F2322 Kit ELISA, 2310035L15Rik Kit ELISA, 5230400G09Rik Kit ELISA, AI414844 Kit ELISA, AI789733 Kit ELISA, DL-M Kit ELISA, Rgmc Kit ELISA, hemojuvelin Kit ELISA, RGMr Kit ELISA, hjv Kit ELISA, id:ibd3464 Kit ELISA, wu:fb38f10 Kit ELISA, zgc:136698 Kit ELISA, hemochromatosis type 2 (juvenile) Kit ELISA, hemochromatosis type 2 Kit ELISA, HFE2 Kit ELISA, Hfe2 Kit ELISA, hfe2 Kit ELISA

Sujet:

Protein Function: Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. .

Background: Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of the repulsive guidance molecule family of proteins. The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Synonyms: Hemojuvelin,Hemochromatosis type 2 protein homolog,RGM domain family member C,Hfe2,Rgmc,

Full Gene Name: Hemojuvelin

Cellular Localisation: Cell membrane, Lipid-anchor, GPI-anchor . Also released in the extracellular space..

UniProt: Q8N7M5

Pathways: Transition Metal Ion Homeostasis