DR3/LARD Kit ELISA

N° du produit ABIN5510736

Détail du produit DR3/LARD Kit ELISA

Antigène: DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))

Épitope: AA 25-201

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human TNFRSF25/DR3

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: Q25-F201

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))

Autre désignation: TNFRSF25 (TNFRSF25 Produits)

Synonymes: APO-3 Kit ELISA, DDR3 Kit ELISA, DR3 Kit ELISA, LARD Kit ELISA, TNFRSF12 Kit ELISA, TR3 Kit ELISA, TRAMP Kit ELISA, WSL-1 Kit ELISA, WSL-LR Kit ELISA, Tnfrsf12 Kit ELISA, Wsl Kit ELISA, TNFRSF25 Kit ELISA, TNF receptor superfamily member 25 Kit ELISA, tumor necrosis factor receptor superfamily, member 25 Kit ELISA, TNFRSF25 Kit ELISA, Tnfrsf25 Kit ELISA

Sujet:

Protein Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

Background: Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.

Synonyms: Tumor necrosis factor receptor superfamily member 25,Apo-3,Apoptosis-inducing receptor AIR,Apoptosis-mediating receptor DR3,Apoptosis-mediating receptor TRAMP,Death receptor 3,Lymphocyte-associated receptor of death,LARD,Protein WSL,Protein WSL-1,TNFRSF25,APO3, DDR3, DR3, TNFRSF12, WSL, WSL1,UNQ455/PRO779,

Full Gene Name: Tumor necrosis factor receptor superfamily member 25

Cellular Localisation: Isoform 1: Cell membrane, Single-pass type I membrane protein.

UniProt: Q93038

Pathways: Apoptose