MAP3K8 Protein (GST tag)

N° du produit ABIN7317083

Détail du produit

Antigène: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette MAP3K8 protéine est marqué à la GST tag.

Fonction: Recombinant Human TPL2/MAP3K8/MEKK8 Protein (GST Tag)

Séquence: Met 30-Arg 397

Attributs du produit: A DNA sequence encoding the human MAP3K8 isoform 1 (P41279-1) (Met 30-Arg 397) was fused with the GST tag at the N-terminus.

Pureté: > 91 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM GSH, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

Autre désignation: TPL2/MAP3K8/MEKK8 (MAP3K8 Produits)

Synonymes: MAP3K8 Protein, COT Protein, EST Protein, ESTF Protein, MEKK8 Protein, TPL2 Protein, Tpl-2 Protein, c-COT Protein, Cot Protein, Cot/Tpl2 Protein, Est Protein, Estf Protein, Tpl2 Protein, D17TPL2 Protein, mitogen-activated protein kinase kinase kinase 8 Protein, MAP3K8 Protein, map3k8 Protein, Map3k8 Protein

Sujet:

Background: Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K8 is expressed in several normal tissues and human tumor-derived cell lines. Isoform 1 of MAP3K8 is activated specifically during the S and G2/M phases of the cell cycle. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway. It is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. MAP3K8 plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein. MAP3K8 oncogene linked to human endometrial carcinoma suggesting that it may be another molecule involved in human endometrial cancer. MAP3K8 may also be an important mediator of intracellular mechanotransduction in human bone marrow-derived mesenchymal stem cells (MSCs).

Synonym: AURA2;c-COT;COT;EST;ESTF;MEKK8;Tpl-2;TPL2

Poids moléculaire: 68 kDa

Pathways: Signalisation PI3K-Akt, TCR Signaling