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Mammalian Monoclonal FGF12 Primary Antibody pour ISt, IHC - ABIN1304629
Wildburger, Ali, Hsu, Shavkunov, Nenov, Lichti, LeDuc, Mostovenko, Panova-Elektronova, Emmett, Nilsson, Laezza: Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. dans Molecular & cellular proteomics : MCP 2015
Human Monoclonal FGF12 Primary Antibody pour IHC (p), ELISA - ABIN560869
Chattopadhyay, Singh, Phukan, Purkayastha, Kataki, Mahanta, Saxena, Kapur: Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India. dans Mutation research 2010
In this study, the authors observed that rs1460922 of FGF12 was significantly associated with VT and identified that a de novo variation of FGF12 may be an important genetic risk factor for the pathogenesis of VT.
FGF12, RBFOX1 (Montrer A2BP1 Anticorps), and MIR302F could be important in human heterotaxy, because they were noted in multiple cases. Further investigation into genes involved in the NODAL, BMP, and WNT (Montrer WNT2 Anticorps) body patterning pathways and into the dosage effects of FGF12, RBFOX1 (Montrer A2BP1 Anticorps), and MIR302F is warranted.
FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation.
Results demonstrate that gain-of-function FHF mutations can cause neurologic disorder, and expand the repertoire of genetic causes (FHF1) and mechanisms (altered Nav gating) underlying early-onset epileptic encephalopathies and cerebellar atrophy
Nine SNPs of the FGF12 gene were associated with Kashin-Beck disease.
Data indicate that SCN5A (Montrer SCN5A Anticorps) variant (Nav1.5 (Montrer SCN5A Anticorps)) p.H1849R affected interaction with fibroblast growth factor homologous factor (FHFs).
Q7R-FGF12 is a disease-associated BrS mutation. Moreover, these data suggest for the first time that FHF effects on Na(+) and Ca(2 (Montrer CA2 Anticorps)+) channels are separable.
VAX1 (Montrer VAX1 Anticorps) rs10787760, rs6585429 and rs1871345 polymorphisms may be involved in nonsyndromic cleft lip with or without cleft palate in Brazilian patients, but there is no association with polymorphisms in FGF12, VCL (Montrer VCL Anticorps), or CX43 (Montrer GJA1 Anticorps)
PHOX2B (Montrer PHOX2B Anticorps), FGF12 and GAD2 (Montrer GAD2 Anticorps) genes are hypermethylated in colorectal neoplastic tissue
exogenous FGF12 can play a role in tissues by translocating into cells through the plasma membrane
FGF21 (Montrer FGF21 Anticorps) does not appear necessary for exercise-induced systemic and hepatic mitochondrial adaptations, but the increased adiposity, hyperinsulinemia, and impairments in hepatic mitochondrial function induced by FGF21 (Montrer FGF21 Anticorps) deficiency can be partially rescued by daily wheel running exercise.
x-ray crystal structure of FHF1b
results argue strongly against the possibility that FHF1 has a modulatory effect on the Na(v)1.9 sodium channel isoform in cRet (Montrer RET Anticorps)+/IB4+ neurons, but FHF1 could play a role in a distinct subset of TrkA (Montrer NTRK1 Anticorps)+/CGRP (Montrer CALCA Anticorps)+ nociceptors.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
fibroblast growth factor 12
, Fibroblast growth factor 12
, fibroblast growth factor 12B
, fibroblast growth factor FGF-12b
, fibroblast growth factor homologous factor 1
, myocyte-activating factor
, fibroblast growth factor homologous factor 1b