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Bat Polyclonal NDFIP2 Primary Antibody pour WB - ABIN610876
Jones, Jakubowicz, Pitossi, Maurer, Hemmings: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. dans Proceedings of the National Academy of Sciences of the United States of America 1991
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Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi.
PTEN/Akt (Montrer AKT1 Anticorps) and MAP kinase (Montrer MAPK1 Anticorps) signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 (Montrer NDFIP1 Anticorps) and Ndfip2
N4WBP5A may play a regulatory role in modulating Nedd4 activity at the level of the Golgi apparatus in T lymphocytes
N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery
Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them.
Ndfip2 controls DMT1 (Montrer SLC11A2 Anticorps) in the liver with female mice showing a greater response to altered dietary iron than the male mice
Data indicate thar Janus kinase 1 (Jak1 (Montrer JAK1 Anticorps)) degradation is dependent on Nedd4 family interacting proteins Ndfip1 (Montrer NDFIP1 Anticorps)/Ndfip2.
DMT1 (Montrer SLC11A2 Anticorps) interacts with 2 WW domain (Montrer DRP2 Anticorps)-interacting proteins, Ndfip1 (Montrer NDFIP1 Anticorps) and Ndfip2. This promotes DMT1 (Montrer SLC11A2 Anticorps) ubiquitination and degradation by WWP2 (Montrer WWP2 Anticorps).
Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling.
Nedd4 family interacting protein 2
, NEDD4 family-interacting protein 2
, MAPK-activating protein PM04 PM05 PM06 PM07
, NEDD4 WW domain-binding protein 5A
, NF-kappa-B-activating protein 413
, putative MAPK-activating protein PM04/PM05/PM06/PM07
, putative NF-kappa-B-activating protein 413