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Zinc-alpha-2-glycoprotein (human) Matched Pair Detection Set

ELISA Reactivité: Humain ELISA unconjugated Hôte: Souris
N° du produit ABIN6253508
  • Antigène Tous les produits AZGP1
    AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))
    Reactivité
    Humain
    Méthode de détection
    Colorimetric
    Hôte
    Souris
    Type de méthode
    Sandwich ELISA
    Gamme de detection
    0.0156 ng/mL - 1 ng/mL
    Seuil minimal de détection
    0.0156 ng/mL
    Application
    ELISA
    Fonction
    Zinc-alpha-2-glycoprotein (human) Matched Pair Detection Set
    Sensibilité
    100 pg/mL
    Attributs du produit
    Matched Pair Detection Set. Detects human Zinc-alpha-2-glycoprotein. Does not detect mouse Zinc-alpha-2-glycoprotein. Colorimetric assay. Sample Type: Cell Culture Supernatant, Plasma, Serum. Range: 0.0156 to 1 ng/mL. Sensitivity: 100 pg/mL. Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.
    Ingrédients
    1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (120μl) [COAT] 1 vial detection antibody (60μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
  • Restrictions
    For Research Use only
  • Concentration
    Lot specific
    Conseil sur la manipulation
    Avoid freeze/thaw cycles.
    Stock
    -20 °C
    Stockage commentaire

    Short Term Storage: -20°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.

  • Antigène
    AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))
    Autre désignation
    Zinc-alpha-2-glycoprotein (AZGP1 Produits)
    Synonymes
    Zag Matched Antibody Pair, ZA2G Matched Antibody Pair, ZAG Matched Antibody Pair, ZA2GA Matched Antibody Pair, Zna2gp Matched Antibody Pair, alpha-2-glycoprotein 1, zinc Matched Antibody Pair, alpha-2-glycoprotein 1, zinc-binding Matched Antibody Pair, Azgp1 Matched Antibody Pair, AZGP1 Matched Antibody Pair
    Sujet

    Alternate Names/Synonyms: Zn-alpha-2-GP, Zn-alpha-2-Glycoprotein, ZAG, ZA2G, AZGP1, ZNGP1

    Product Description: Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.

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