Breast Cancer 1 (BRCA1) (N-Term) Peptide
BRCA1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits BRCA1
- BRCA1 (Breast Cancer 1 (BRCA1))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- DLSALRVEEV QNVINAMQKI LECPICLELI KEPVSTKCDH IFCKFCMLKL
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-BRCA1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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-
- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Antigène
- BRCA1 (Breast Cancer 1 (BRCA1))
- Synonymes
- BRCAI Peptide, BRCC1 Peptide, BROVCA1 Peptide, IRIS Peptide, PNCA4 Peptide, PPP1R53 Peptide, PSCP Peptide, RNF53 Peptide, iris Peptide, pscp Peptide, brcai Peptide, brcc1 Peptide, rnf53 Peptide, brca1 Peptide, BRCA1 Peptide, LOC100224649 Peptide, BRCA1, DNA repair associated Peptide, breast cancer 1 Peptide, breast cancer 1, early onset Peptide, breast cancer 1 L homeolog Peptide, BRCA1 Peptide, brca1 Peptide, LOC755086 Peptide, Brca1 Peptide, brca1.L Peptide
- Sujet
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The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.
Alias Symbols: BRCAI, BRCC1, IRIS, PSCP, RNF53
Protein Interaction Partner: ETS2,CREBBP,EP300,MAP3K3,MED1,BRCA1,SMAD2,SMAD3,SMAD4,UBB,ACACA,ATR,BRCA2,CCNA1,CCNB1,CCND1,CDK2,CDK4,CSNK2B,E2F1,E2F4,FANCA,HDAC1,HDAC2,JUN,JUNB,JUND,LMO4,MSH2,MSH6,MYC,NFYA,NMI,NUFIP1,POU2F1,RAD51,RAD51,RB1,RBBP4,RBBP7,RBBP8,SP1,TP53,TP53,ABL1,ACACA,AKT
Protein Size: 680 - Poids moléculaire
- 76 kDa
- ID gène
- 672
- NCBI Accession
- NM_007298, NP_009229
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