Telomerase Reverse Transcriptase (TERT) (C-Term) Peptide
TERT
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TERT
- TERT (Telomerase Reverse Transcriptase (TERT))
- Protein Region
- C-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- HQAFLLKLTR HRVTYVPLLG SLRTAQTQLS RKLPGTTLTA LEAAANPALP
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TERT Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TERT (Telomerase Reverse Transcriptase (TERT))
- Synonymes
- CMM9 Peptide, DKCA2 Peptide, DKCB4 Peptide, EST2 Peptide, PFBMFT1 Peptide, TCS1 Peptide, TP2 Peptide, TRT Peptide, hEST2 Peptide, hTRT Peptide, chTERT Peptide, Tert Peptide, ATTERT Peptide, F5E19.190 Peptide, F5E19_190 Peptide, telomerase reverse transcriptase Peptide, tert Peptide, TR Peptide, est2 Peptide, tcs1 Peptide, telomerase Peptide, tert-A Peptide, tp2 Peptide, trt Peptide, xTERT Peptide, telomerase reverse transcriptase Peptide, Telomerase Reverse Transcriptase Peptide, Tertp Peptide, Telomerase catalytic subunit Peptide, telomerase reverse transcriptase L homeolog Peptide, TERT Peptide, trt-1 Peptide, Tert Peptide, tert Peptide, CMU_003490 Peptide, VDBG_04487 Peptide, GL50803_16225 Peptide, tert.L Peptide
- Sujet
-
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Alias Symbols: DKCA2, DKCB4, EST2, TCS1, TP2, TRT, hEST2, hTRT
Protein Size: 1132 - Poids moléculaire
- 127 kDa
- ID gène
- 7015
- NCBI Accession
- NM_198253, NP_937983
- UniProt
- O14746
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