Deiodinase, Iodothyronine, Type II (DIO2) (Middle Region) Peptide
DIO2
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits DIO2
- DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- ILLKHVVLLL SRSKSTRGEW RRMLTSEGLR CVWKSFLLDA YKQVKLGEDA
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-DIO2 (ARP78117_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))
- Synonymes
- 5DII Peptide, D2 Peptide, DIOII Peptide, SelY Peptide, TXDI2 Peptide, AI324267 Peptide, Deio2 Peptide, cb684 Peptide, DIO2 Peptide, dio2-A Peptide, 5dii Peptide, sely Peptide, txdi2 Peptide, iodothyronine deiodinase 2 Peptide, deiodinase, iodothyronine, type II Peptide, deiodinase, iodothyronine, type 2 L homeolog Peptide, deiodinase, iodothyronine, type 2 Peptide, type II iodothyronine deiodinase Peptide, DIO2 Peptide, Dio2 Peptide, dio2 Peptide, dio2.L Peptide, LOC100861220 Peptide
- Sujet
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The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: D2, 5DII, SelY, DIOII, TXDI2
Protein Size: 273 - ID gène
- 1734
- NCBI Accession
- NM_000793, NP_000784
- UniProt
- Q92813
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