Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (Middle Region) Peptide
PICALM
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits PICALM
- PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- NLGIGNGTTK NDVNWSQPGE KKLTGGSNWQ PKVAPTTAWN AATMAPPVMA
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- PICALM Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
- Synonymes
- LAP-3 Peptide, PEPS Peptide, CALM Peptide, CLTH Peptide, LAP Peptide, PAP180 Peptide, fit-1 Peptide, fit1 Peptide, mKIAA4114 Peptide, Calm Peptide, leucine aminopeptidase 3 Peptide, phosphatidylinositol binding clathrin assembly protein Peptide, si:ch211-200p22.4 Peptide, LAP3 Peptide, PICALM Peptide, Picalm Peptide, si:ch211-200p22.4 Peptide
- Sujet
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This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: LAP, CALM, CLTH
Protein Size: 551 - ID gène
- 8301
- NCBI Accession
- NM_001008660, NP_001008660
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