SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (Middle Region) Peptide
SHC1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits SHC1
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- ELRFKQYLRN PPKLVTPHDR MAGFDGSAWD EEEEEPPDHQ YYNDFPGKEP
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- SHC1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- Synonymes
- SHC1 Peptide, SHC Peptide, SHCA Peptide, P66shc Peptide, si:dkey-246i14.4 Peptide, wu:fc10h03 Peptide, shc Peptide, p66shc Peptide, Shc Peptide, ShcA Peptide, p66 Peptide, SHC adaptor protein 1 Peptide, Shc1p Peptide, squalene--hopene cyclase Peptide, SHC (Src homology 2 domain containing) transforming protein 1 Peptide, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog Peptide, src homology 2 domain-containing transforming protein C1 Peptide, SHC1 Peptide, shc1 Peptide, Shc1 Peptide, shc1.L Peptide
- Sujet
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This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: SHC, SHCA
Protein Size: 473 - ID gène
- 6464
- NCBI Accession
- NM_001130040, NP_001123512
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