Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Attributs du produit
This is a synthetic peptide designed for use in combination with anti-MCM6 antibody (Catalog #: ARP36650_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The protein encoded by the MCM6 gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.
Alias Symbols: MCG40308, Mis5, P105MCM
Protein Interaction Partner: MCM2,MCM2,MCM4,MCM4,MCM6,ALS2CR11,CCNA1,CDT1,CRLS1,GMNN,IL1F5,ING5,MCM10,MCM2,MCM3,MCM4,MCM6,MCM7,MCM8,MLLT3,ORC2L,ORC6L,PSMA1,SCNM1,SMC1A,AIRE,ALS2CR11,CDC45,CDT1,IL1F5,ING5,MCM10,MCM2,MCM4,MCM5,MCM6,MCM7,MCM8,MLLT3,ORC1L,ORC2L,ORC4L,PMS1,PSMA1,RPA1,SCNM1,TAF10,TNFAIP3,USP49,USP7