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Retinoblastoma-Like 1 (p107) (RBL1) (Middle Region) Peptide

RBL1 Reactivité: Humain, Souris Hôte: Synthetic BP, WB
N° du produit ABIN982719
  • Antigène Tous les produits p107 (RBL1)
    p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
    Protein Region
    Middle Region
    Origine
    Humain, Souris
    Source
    • 2
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Attributs du produit
    This is a synthetic peptide designed for use in combination with anti-RBL1 antibody (Catalog #: ARP32490_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Indications d'application
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Antigène
    p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
    Synonymes
    p107 Peptide, prb1 Peptide, fj58e06 Peptide, wu:fj58e06 Peptide, CP107 Peptide, PRB1 Peptide, AW547426 Peptide, retinoblastoma-like 1 L homeolog Peptide, RB transcriptional corepressor like 1 Peptide, retinoblastoma-like 1 (p107) Peptide, retinoblastoma-like 1 Peptide, rbl1.L Peptide, RBL1 Peptide, rbl1 Peptide, Rbl1 Peptide
    Sujet
    RBL1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor.The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

    Alias Symbols: CP107, MGC40006, PRB1, p107

    Protein Interaction Partner: RB1,E2F1,E2F2,E2F4,RBL2,E2F4,BEGAIN,BRF1,CCNA1,CCNA2,CCND1,CCNE1,CDK2,CDK4,CEBPA,CREG1,DGKZ,DHX30,E2F4,E2F5,HDAC1,ID2,KDM5A,MCM7,MYBL2,MYC,NR2E3,PHB,PPP2R3A,RBBP8,RBBP9,RBL1,SMAD2,SMAD3,SMAD4,SNW1,SP1,SUV39H1,SUV420H2,TAF1,USP4,AATF,ARID4A,BEGAIN,BRCA1,BRF1,CCNA1,CCNA2,CCNE1,CDK2,CDKN1C,CREG1,E2F1,E2F4,E2F5,HDAC1,HDAC2,HDAC3,KDM5A,LIN9,MCM7,MCM7,MT1G,MYBL2,MYC,PHB,PPP2R3A,RB1,RBBP8,RBBP9,SMAD3,SMAD4,SNW1,SUV39H1,TAF1,TFDP1,TFDP2,USP4,UXT

    Protein Size: 1068
    Poids moléculaire
    121 kDa
    ID gène
    5933
    NCBI Accession
    NM_002895, NP_002886
    UniProt
    P28749
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