TANK-Binding Kinase 1 (TBK1) Peptide
TBK1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TBK1
- TBK1 (TANK-Binding Kinase 1 (TBK1))
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TBK1 antibody (Catalog #: ARP54921_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TBK1 (TANK-Binding Kinase 1 (TBK1))
- Synonymes
- nak Peptide, t2k Peptide, TBK1 Peptide, wu:fk70c05 Peptide, zgc:136548 Peptide, NAK Peptide, T2K Peptide, 1200008B05Rik Peptide, AI462036 Peptide, AW048562 Peptide, TANK binding kinase 1 L homeolog Peptide, TANK binding kinase 1 Peptide, TANK-binding kinase 1 Peptide, tbk1.L Peptide, TBK1 Peptide, tbk1 Peptide, Tbk1 Peptide
- Sujet
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The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TBK1 is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ11330, NAK, T2K
Protein Interaction Partner: TICAM1,AZI2,CDC37,HSP90AA1,HSP90AB1,IKBKB,IKBKG,IRF3,IRF5,MAVS,NCK1,NFKBIA,RELA,SIKE1,TANK,TBK1,TICAM1,TRAF2,ANKRD28,BTRC,CDC37,CUL1,CYLD,HSP90AA2,IKBKG,IRF3,NCK1,NFKB1,NFKB2,PPP6C,PPP6R1,PPP6R2,REL,RELA,SKP1,TANK,TBKBP1,TNFAIP3,TRAF2,TRAF3,UBC
Protein Size: 729 - Poids moléculaire
- 84 kDa
- ID gène
- 29110
- NCBI Accession
- NM_013254, NP_037386
- UniProt
- Q9UHD2
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