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anti-Human BOK Anticorps:
anti-Rat (Rattus) BOK Anticorps:
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Human Polyclonal BOK Primary Antibody pour IHC (p), WB - ABIN388103
Hsu, Kaipia, McGee, Lomeli, Hsueh: Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. dans Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 4 Pubmed References
Loss of BOK is associated with non-small-cell lung carcinoma.
These results not only establish Bok as a Bak (Montrer BAK1 Anticorps)- and Bax (Montrer BAX Anticorps)-independent apoptosis inducer, but also suggest a potential impact of Bok expression in ovarian cancer therapy.
Data suggest that endoplasmic reticulum (ER) stress-induced apoptosis in hepatoma cells is regulated by highly labile and ER-associated BCL-2 (Montrer BCL2 Anticorps) family member BOK, which is controlled at level of protein stability by ER-associated degradation components; DNAJB12 (Montrer DNAJB12 Anticorps) is required in hepatoma cells to maintain BOK at low levels and suppress ER stress. (DNAJB12 (Montrer DNAJB12 Anticorps) = DnaJ (Hsp40 (Montrer DNAJB1 Anticorps)) homolog (Montrer DNAJB4 Anticorps), subfamily B (Montrer CYP Anticorps), member 12)
Data suggest that hypoxia-induced expression of BOK in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A (Montrer HIF1A Anticorps), HIF2A/EPAS1 (Montrer EPAS1 Anticorps), HIF1B/ARNT (Montrer ARNT Anticorps)) but is not affected by its antisense transcript.
First evidence for a key role of the BOK-MCL1 (Montrer MCL1 Anticorps) system in regulating autophagy in the human placenta, whereby an adverse environment as seen in preeclampsia tilts the BOK-MCL1 (Montrer MCL1 Anticorps) balance toward the build-up of isoforms that triggers placental autophagy.
Bok may govern IP3R (Montrer ITPR1 Anticorps) cleavage and activity during apoptosis.
The results suggest important roles for Bok and Bcl-X(L (Montrer BCL2L1 Anticorps)) in human ovarian development, follicle maturation and apoptosis.
Data conclude that Mtd (Montrer MT1E Anticorps)-L functions to regulate trophoblast cell proliferation during early placentation and that the elevated levels of Mtd (Montrer MT1E Anticorps) found in PE may contribute to increased trophoblast proliferation.
BOK and NOXA (Montrer PMAIP1 Anticorps) are essential mediators of p53 (Montrer TP53 Anticorps)-dependent apoptosis
A novel Mtd/BOK splice isoform is responsible for trophoblast cell death in pre-eclampsia.
we show that BOK(C) can permeabilize liposomes, and cooperate with cBID, but its role in directly mediating mitochondrial permeabilization is unclear and may underlie a yet to be determined negative regulation.
Bok controls neuronal Ca(2 (Montrer CA2 Anticorps)+) homeostasis and bioenergetics in seizure-induced neuronal injury.
Study reports that BCL-2 (Montrer BCL2 Anticorps) ovarian killer (BOK) is a bona fide yet unconventional effector of mitochondrial outer membrane permeabilization that can trigger apoptosis in the absence of both BAX (Montrer BAX Anticorps) and BAK (Montrer BAK1 Anticorps).
findings support a selective and distinguishing role for BOK in regulating the apoptotic response to ER stress, revealing--to our knowledge--the first bona fide apoptotic defect linked to Bok deletion
BOK-deficient mice have no readily discernible abnormalities, and its function therefore remains unresolved.
two proapoptotic Bcl-2 family members Bok and Noxa/Pmaip are directly transcriptionally induced by activated MAL and upon activation of the actin-MAL-SRF pathway
Bok protein have a role that largely overlaps with that of other members of the Bcl-2 (Montrer BCL2 Anticorps) family, or may have a function restricted to specific stress stimuli and/or tissues.
Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 (Montrer BCL2 Anticorps) family
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family.
bcl-2-related ovarian killer protein
, BCL2-related ovarian killer
, Bcl-2-related ovarian killer
, bcl-2-related ovarian killer protein homolog A
, bcl-2-related ovarian killer protein homolog B
, bcl-2-like protein 9
, apoptosis activator Mtd
, protein matador