SUMO1 Protein (AA 1-101) (His tag)

N° du produit ABIN1097601

Détail du produit

Antigène: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-101

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SUMO1 protéine est marqué à la His tag.

Fonction: Recombinant Human Small Ubiquitin-Related Modifier 1/SUMO1 (N-6His)

Séquence: MGSSHHHHHH SSGLVPRGSH MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN SLRFLFEGQR IADNNTPKEL GMEEEDVIEV YQEQTGGHST V

Attributs du produit: Recombinant Human Small Ubiquitin-Related Modifier 1/SUMO1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1­Val101) of Human SUMO1.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM TrisHCl, 100 mM NaCl, 1 mM DTT, pH 8.5 .

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Autre désignation: Small Ubiquitin-Related Modifier 1/SUMO1 (SUMO1 Produits)

Synonymes: DAP1 Protein, GMP1 Protein, OFC10 Protein, PIC1 Protein, SENP2 Protein, SMT3 Protein, SMT3C Protein, SMT3H3 Protein, UBL1 Protein, hm:zeh0670 Protein, wu:fb74c02 Protein, wu:fd12c02 Protein, zgc:65934 Protein, zgc:85634 Protein, SUMO1 Protein, dap1 Protein, gmp1 Protein, ofc10 Protein, pic1 Protein, senp2 Protein, smt3 Protein, smt3c Protein, sumo-1 Protein, sumo1 Protein, ubl1 Protein, xsumo-1 Protein, xsumo1 Protein, ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1 Protein, ATSUMO1 Protein, F10M23.180 Protein, F10M23_180 Protein, SMALL UBIQUITIN-LIKE MODIFIER 1 Protein, SUM1 Protein, SUMO 1 Protein, small ubiquitin-like modifier 1 Protein, pigSUMO1 Protein, SENTRIN Protein, SMTP3 Protein, SUMO-1 Protein, Smt3C Protein, Ubl1 Protein, small ubiquitin-like modifier 1 Protein, small ubiquitin-like modifier 1 S homeolog Protein, small ubiquitin-related protein 1 Protein, SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) Protein, SMT3 suppressor of mif two 3 homolog 1 (yeast) Protein, small ubiquitin-like modifier 1 L homeolog Protein, Sumo1 Protein, SUMO1 Protein, sumo1 Protein, sumo1.S Protein, sumo-1 Protein, sumo1.L Protein

Sujet: Small Ubiquitin-Related Modifier 1 (SUMO1) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO1 functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 is not active until the last four amino acids of the carboxy-terminus are cleaved off. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins and may also regulate a network of genes involved in palate development.
Alternative Names: Small Ubiquitin-Related Modifier 1, SUMO-1, GAP-Modifying Protein 1, GMP1, SMT3 Homolog 3, Sentrin, Ubiquitin-Homology Domain Protein PIC1, Ubiquitin-Like Protein SMT3C, Smt3C, Ubiquitin-Like Protein UBL1, SUMO1, SMT3C, SMT3H3, UBL1

Poids moléculaire: 13.7 kDa

UniProt: P63165

Pathways: M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway