NMRAL1 Protein (His tag)

N° du produit ABIN1098305

Détail du produit

Antigène: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette NMRAL1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Purification: purified by chromatography

Pureté: > 95 % by SDS - PAGE

Information d'application

Commentaires:

Synonyms: NmrA-like family domain containing 1, HSCARG, SDR48A1

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol 0.15 M NaCl

Stock: 4 °C

Stockage commentaire: Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Autre désignation: NMRAL1 (NMRAL1 Produits)

Synonymes: HSCARG Protein, SDR48A1 Protein, 1110025F24Rik Protein, AI256624 Protein, RGD1311451 Protein, NmrA like redox sensor 1 Protein, NmrA-like family domain containing 1 Protein, NMRAL1 Protein, Nmral1 Protein

Sujet: NMRAL1 is a redox sensor protein that undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. Recombinant human NMRAL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 35.9kDa(323aa) confirmed by MALDI-TOF

NCBI Accession: NP_065728