CDK2AP2 Protein (His tag)
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- Antigène Voir toutes CDK2AP2 Protéines
- CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette CDK2AP2 protéine est marqué à la His tag.
- Application
- SDS-PAGE (SDS)
- Purification
- purified by chromatography
- Pureté
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product CDK2AP2 Protéine
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- Commentaires
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Synonyms: cyclin-dependent kinase 2 associated protein 2, DOC-1R, p14
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 50% glycerol, 2 mM DTT
- Stock
- 4 °C
- Stockage commentaire
- Avoid repeated freezing and thawing cycles.
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- Antigène
- CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2 (CDK2AP2))
- Autre désignation
- CDK2AP2 (CDK2AP2 Produits)
- Synonymes
- DOC-1R Protein, p14 Protein, zgc:92182 Protein, 5830466O21Rik Protein, D19Ertd144e Protein, Doc-1r Protein, cyclin dependent kinase 2 associated protein 2 Protein, cyclin-dependent kinase 2 associated protein 2 Protein, CDK2-associated protein 2 Protein, CDK2AP2 Protein, cdk2ap2 Protein, Cdk2ap2 Protein
- Sujet
- CDK2AP2, also known as DOC-1R and p14, belongs to the CDK2AP family. CDK2-associated protein is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. CDK2AP2 is a regulator for self-renewal of mouse embryonic stem cells (mESCs) under permissive conditions, and cell survival during differentiation of the mESCs into terminally differentiated cell types. CDK2AP2 may be involved in the regulation of self-renewal of stem cells during early embryogenesis. Recombinant human CDK2AP2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Poids moléculaire
- 15.5kDa (149aa), confirmed by MALDI-TOF
- NCBI Accession
- NP_005842
- Pathways
- Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
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