TNFRSF10B Protein (AA 52-212, Extracellular Domain) (Fc Tag)
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- Antigène Voir toutes TNFRSF10B Protéines
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- Extracellular Domain, AA 52-212
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Origine
- Humain, Souris
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette TNFRSF10B protéine est marqué à la Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificité
- Binds to human and mouse TRAIL.
- Réactivité croisée
- Humain, Souris
- Attributs du produit
- The extracellular domain of human TRAIL-R2 (aa 52-212) is fused to the Fc portion of human IgG1.
- Pureté
- >95 % (SDS-PAGE)
- niveau d'endotoxine
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFRSF10B Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Blocks human or mouse TRAIL activity in a concentration of 1-10μg/ml.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 50 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Date de péremption
- 6 months
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- Antigène
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
- Autre désignation
- TRAIL-R2 (TNFRSF10B Produits)
- Synonymes
- TNFRSF10B Protein, dr5 Protein, cd262 Protein, killer Protein, trick2 Protein, trickb Protein, xDR-M1 Protein, xDR-M2 Protein, ztnfr9 Protein, trailr2 Protein, trick2a Protein, trick2b Protein, CD262 Protein, DR5 Protein, KILLER Protein, KILLER/DR5 Protein, TRAIL-R2 Protein, TRAILR2 Protein, TRICK2 Protein, TRICK2A Protein, TRICK2B Protein, TRICKB Protein, ZTNFR9 Protein, Ly98 Protein, MK Protein, tumor necrosis factor receptor superfamily, member 10b Protein, tumor necrosis factor receptor superfamily member 10b S homeolog Protein, tumor necrosis factor receptor superfamily member 10b L homeolog Protein, tumor necrosis factor receptor superfamily member 10b Protein, TNF receptor superfamily member 10b Protein, Tnfrsf10b Protein, TNFRSF10B Protein, tnfrsf10b.S Protein, tnfrsf10b.L Protein, tnfrsf10b Protein
- Sujet
- TRAIL-R2 (DR5, CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
- Poids moléculaire
- ~50kDa (SDS-PAGE)
- UniProt
- O14763
- Pathways
- Signalisation p53, Apoptose, Positive Regulation of Endopeptidase Activity
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