IL-2 Protéine

N° du produit ABIN1589645

Détail du produit

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Séquence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFCQSII STLHYKDPAA NKARKEAELA AATAEQ

Attributs du produit: Length (AA): 156
Chromosomal location: 4q26-q27
The ED50 as determined by the dose-dependent stimulation of proliferation of murine D10G4.1 cells is in the range of 0.1-0.5 ng/mL.

Pureté: > 98 % by SDS-PAGE. Visualized by silver stain

niveau d'endotoxine: < 0.1 ng per µg of IL-2

Information d'application

Commentaires:

Cytokines & Growth Factors

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: The lyophilized IL-2 should be reconstituted in 50 mM acetic acid to a concentration not less than 100 μg/mL. This solution can be diluted into other buffered solutions or stored at -20 °C for future use.

Buffer: 50 mM acetic acid

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: 0 °C

Stockage commentaire: The lyophilized IL-2, though stable at room temperature, is best stored desiccated below 0 °C. Reconstituted IL-2 should be stored in workingaliquots at -20 °C.

Référence

Haustein, Ramer, Linnebacher, Manda, Hinz: "Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1." dans: Biochemical pharmacology, Vol. 92, Issue 2, pp. 312-25, (2014) (PubMed).

Détail du antigène

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Autre désignation: IL-2 (IL2 Produits)

Synonymes: IL2 Protein, IL-2 Protein, il2 Protein, TCGF Protein, lymphokine Protein, Il-2 Protein, POIL2 Protein, interleukin 2 Protein, interleukin-15 Protein, IL2 Protein, il2 Protein, LOC100303688 Protein, Il2 Protein

Sujet: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 (modified at the C-terminal end) is a 15.5 kDa protein, containing 156 amino acid residues including one intrachain disulfide bond.
Synonyms: IL2, IL-2, TCGF, lymphokine

Poids moléculaire: 15.5 kDa

NCBI Accession: NP_000577, NM_000586

UniProt: P60568

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation