CD3D Protein (AA 22-105) (His tag)
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- Antigène Voir toutes CD3D Protéines
- CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 22-105
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Origine
- Cynomolgus
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD3D protéine est marqué à la His tag.
- Séquence
- AA 22-105
- Attributs du produit
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.3 kDa. The protein migrates as 26-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Pureté
- >90 % as determined by SDS-PAGE.
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CD3D Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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- Antigène
- CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))
- Autre désignation
- CD3 delta (CD3D Produits)
- Synonymes
- CD3-DELTA Protein, T3D Protein, CD3 Protein, T3d Protein, CD3d molecule Protein, CD3 antigen, delta polypeptide Protein, CD3D Protein, Cd3d Protein
- Sujet
- CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
- Poids moléculaire
- 14.3 kDa
- UniProt
- Q95LI8
- Pathways
- TCR Signaling, CXCR4-mediated Signaling Events
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