XBP1 Protein (AA 2-160) (His tag)

N° du produit ABIN2469226

Protéine Recombinant XBP1 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour XBP1 Protein (AA 2-160) (His tag) (ABIN2469226)

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)

Pureté: ~95 %

Détail du produit

Attributs du protein: AA 2-160

Purification/Conjugué: Cette XBP1 protéine est marqué à la His tag.

Information d'application

Indications d'application: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1X PBS containing 0.1 % SDS

Conseil sur la manipulation: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -80 °C

Stockage commentaire: Store in working aliquots at -70 °C.

Détail du antigène

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Autre désignation: XBP1

Sujet: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) (1). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).

Poids moléculaire: 25 kDa (Calculated)

ID gène: 7494

OMIM: 18148382

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response