Complement Factor I Protein (CFI) (Myc-DYKDDDDK Tag)

N° du produit ABIN2712460

Détail du produit

Antigène: Complement Factor I (CFI)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Complement Factor I protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Complement factor I protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: Complement Factor I (CFI)

Autre désignation: Complement Factor I (CFI Produits)

Synonymes: cfi Protein, MGC53615 Protein, Cfi Protein, factor I Protein, IF Protein, gb:ai721528 Protein, ahus3 Protein, c3b-ina Protein, c3bc4bi Protein, c3bina Protein, kaf Protein, CFI Protein, AHUS3 Protein, C3BINA Protein, C3b-INA Protein, FI Protein, KAF Protein, complement factor I S homeolog Protein, complement factor I L homeolog Protein, complement factor I Protein, complement component factor i Protein, cfi.S Protein, cfi.L Protein, CFI Protein, cfi Protein, Cfi Protein

Sujet: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.

Poids moléculaire: 63.4 kDa

NCBI Accession: NP_000195

Pathways: Système du Complément