Coagulation Factor X Protein (F10) (Myc-DYKDDDDK Tag)

N° du produit ABIN2712927

Détail du produit

Antigène: Coagulation Factor X (F10)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Coagulation Factor X protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Coagulation factor X (F10) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: Coagulation Factor X (F10)

Abstract: F10 Produits

Synonymes: FX Protein, FXA Protein, Cf10 Protein, fX Protein, fi12c10 Protein, wu:fi12c10 Protein, F10 Protein, f10 Protein, coagulation factor X Protein, Coagulation factor X Protein, coagulation factor 10 L homeolog Protein, F10 Protein, f10 Protein, CpipJ_CPIJ012712 Protein, CpipJ_CPIJ014863 Protein, CpipJ_CPIJ016937 Protein, CpipJ_CPIJ017791 Protein, fa10 Protein, f10.L Protein

Sujet: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Poids moléculaire: 52.3 kDa

NCBI Accession: NP_000495