Dual Specificity Phosphatase 3 (DUSP3) protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2719836

Détail du produit

Antigène: Dual Specificity Phosphatase 3 (DUSP3)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Myc-DYKDDDDK Tag

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human DUSP3 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: Dual Specificity Phosphatase 3 (DUSP3)

Autre désignation: Dusp3 (DUSP3 Produits)

Synonymes: dusp3 Protein, si:bz18k17.3 Protein, si:rp71-18k17.3 Protein, VHR Protein, RGD1560049 Protein, 2210015O03Rik Protein, 5031436O03Rik Protein, T-DSP11 Protein, dual specificity phosphatase 3 Protein, dual specificity phosphatase 3b Protein, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) Protein, DUSP3 Protein, dusp3b Protein, Dusp3 Protein

Classe de substances: Viral Protein

Sujet: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Poids moléculaire: 20.3 kDa

NCBI Accession: NP_004081

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades