Dual Specificity Phosphatase 3 (DUSP3) protein (His tag)

N° du produit ABIN7319414

Détail du produit

Antigène: Dual Specificity Phosphatase 3 (DUSP3)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: His tag

Fonction: Recombinant Human DUSP3/VHR Protein (His Tag)

Séquence: Ser2-Pro185

Attributs du produit: Recombinant Human DUSP3 is produced by our E.coli expression system and the target gene encoding Ser2-Pro185 is expressed with a 6His tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: Dual Specificity Phosphatase 3 (DUSP3)

Autre désignation: DUSP3/VHR (DUSP3 Produits)

Synonymes: dusp3 Protein, si:bz18k17.3 Protein, si:rp71-18k17.3 Protein, VHR Protein, RGD1560049 Protein, 2210015O03Rik Protein, 5031436O03Rik Protein, T-DSP11 Protein, dual specificity phosphatase 3 Protein, dual specificity phosphatase 3b Protein, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) Protein, DUSP3 Protein, dusp3b Protein, Dusp3 Protein

Classe de substances: Viral Protein

Sujet:

Background: Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively regulate members of the mitogen-activated protein kinase superfamily, which are associated with cellular proliferation and differentiation. DUSP3 is expressed in human tissues including breast and ovarian.DUSP3 shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Human DUSP3 specifically dephosphorylates and inactivates ERK1 and ERK2.

Synonym: Dual specificity protein phosphatase 3,DUSP3,Dual specificity protein phosphatase VHR,Vaccinia H1-related phosphatase,VHR

Poids moléculaire: 22.6 kDa

UniProt: P51452

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades