DUSP6 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2719840

Détail du produit

Antigène: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette DUSP6 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human DUSP6 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Autre désignation: Dusp6 (DUSP6 Produits)

Synonymes: HH19 Protein, MKP3 Protein, PYST1 Protein, 1300019I03Rik Protein, MKP-3 Protein, Mkp3 Protein, wu:fd99d09 Protein, mkp3 Protein, pyst1 Protein, DUSP6 Protein, dusp6 Protein, dual specificity phosphatase 6 Protein, dual specificity phosphatase 6 L homeolog Protein, Dual specificity protein phosphatase 6 Protein, DUSP6 Protein, Dusp6 Protein, dusp6 Protein, dusp6.L Protein, dus6 Protein

Sujet: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.

Poids moléculaire: 42.1 kDa

NCBI Accession: NP_001937

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades