EGLN1 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2720024

Détail du produit

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette EGLN1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human EGLN1 / PHD2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Autre désignation: Egln1,phd2 (EGLN1 Produits)

Synonymes: EGLN1 Protein, egln2 Protein, phd2 Protein, zgc:92314 Protein, AI503754 Protein, C1orf12 Protein, HIF-PH2 Protein, HPH-2 Protein, Hif-p4h-2 Protein, ORF13 Protein, Phd2 Protein, SM-20 Protein, PHD-2 Protein, PHD2 Protein, ECYT3 Protein, HIFPH2 Protein, HPH2 Protein, SM20 Protein, ZMYND6 Protein, egl nine homolog 1 (C. elegans) Protein, egl-9 family hypoxia inducible factor 1 Protein, egl-9 family hypoxia-inducible factor 1 S homeolog Protein, egl-9 family hypoxia-inducible factor 1b Protein, egl-9 family hypoxia-inducible factor 1 Protein, EGLN1 Protein, egln1.S Protein, egln1b Protein, Egln1 Protein

Sujet: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Poids moléculaire: 45.8 kDa

NCBI Accession: NP_071334

Pathways: cAMP Metabolic Process, L'effet Warburg