MLH1 Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2726101

Détail du produit

Antigène: MLH1 (MutL Homolog 1 (MLH1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette MLH1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human MLH1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: MLH1 (MutL Homolog 1 (MLH1))

Autre désignation: Mlh1 (MLH1 Produits)

Synonymes: CG11482 Protein, Dmel\\CG11482 Protein, dmlh-1 Protein, dmlh1 Protein, zgc:66301 Protein, MLH1 Protein, LOC100232198 Protein, 1110035C23Rik Protein, AI317206 Protein, AI325952 Protein, AI561766 Protein, COCA2 Protein, FCC2 Protein, HNPCC Protein, HNPCC2 Protein, hMLH1 Protein, mutL homolog 1 Protein, CG11482 gene product from transcript CG11482-RB Protein, mutL homolog 1 S homeolog Protein, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) Protein, DNA mismatch repair protein Mlh1 Protein, MLH1 Protein, Mlh1 Protein, mlh1.S Protein, mlh1 Protein, LOC588545 Protein

Sujet: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009].

Poids moléculaire: 84.4 kDa

NCBI Accession: NP_000240

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response