PHLPP1 Protein (Myc-DYKDDDDK Tag)
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- Antigène Tous les produits PHLPP1
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
- Type de proteíne
- Recombinant
- Origine
- Humain
- Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PHLPP1 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
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- Recombinant human PHLPP1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
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- Indications d'application
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." dans: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
: "An ATP-site on-off switch that restricts phosphatase accessibility of Akt." dans: Science signaling, Vol. 5, Issue 223, pp. ra37, (2012) (PubMed).
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Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression." dans: International immunopharmacology, Vol. 34, pp. 229-34, (2016) (PubMed).
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- Antigène
- PHLPP1 (PH Domain and Leucine Rich Repeat Protein Phosphatase 1 (PHLPP1))
- Autre désignation
- Phlpp1 (PHLPP1 Produits)
- Synonymes
- PHLPP Protein, PLEKHE1 Protein, SCOP Protein, AI836256 Protein, Phlpp Protein, Plekhe1 Protein, mKIAA0606 Protein, Scop Protein, PH domain and leucine rich repeat protein phosphatase 1 Protein, PHLPP1 Protein, phlpp1 Protein, Phlpp1 Protein
- Sujet
- This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
- Poids moléculaire
- 184.5 kDa
- NCBI Accession
- NP_919431
- Pathways
- Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
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