PPARD Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2729419

Détail du produit

Antigène: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PPARD protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human PPAR-delta (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Autre désignation: Ppar-delta (PPARD Produits)

Synonymes: FAAR Protein, NR1C2 Protein, NUC1 Protein, NUCI Protein, NUCII Protein, PPARB Protein, NUC-1 Protein, Nr1c2 Protein, PPAR-beta Protein, PPAR-delta Protein, PPAR[b] Protein, PPARdelta Protein, Pparb Protein, Pparb/d Protein, PPARBETA Protein, ppard Protein, pparb Protein, PPARD Protein, PPAR-D/B Protein, peroxisome proliferator activated receptor delta Protein, peroxisome proliferator activator receptor delta Protein, peroxisome proliferator activated receptor delta S homeolog Protein, peroxisome proliferator-activated receptor delta Protein, PPARD Protein, Ppard Protein, ppard.S Protein, ppard Protein

Sujet: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

Poids moléculaire: 49.7 kDa

NCBI Accession: NP_006229

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation