PTPN12 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
-
- Antigène Voir toutes PTPN12 Protéines
- PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
- Type de proteíne
- Recombinant
- Attributs du protein
- Transcript Variant 1
-
Origine
- Humain
-
Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PTPN12 protéine est marqué à la Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Attributs du produit
-
- Recombinant human PTPN12 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Pureté
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PTPN12 Protéine
-
-
- Indications d'application
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Commentaires
-
The tag is located at the C-terminal.
- Restrictions
- For Research Use only
-
- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Stock
- -80 °C
- Stockage commentaire
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Antigène
- PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
- Autre désignation
- Ptpn12 (PTPN12 Produits)
- Synonymes
- PTP-PEST Protein, PTPG1 Protein, P19-PTP Protein, PTP-P19 Protein, Ptpg1 Protein, RKPTP Protein, protein tyrosine phosphatase, non-receptor type 12 Protein, PTPN12 Protein, Ptpn12 Protein
- Sujet
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- Poids moléculaire
- 87.9 kDa
- NCBI Accession
- NP_002826
-