ROR1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2731082

Détail du produit

Antigène: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Type de proteíne: Recombinant

Attributs du protein: Transcript Variant 1

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ROR1 protéine est marqué à la Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human ROR1 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Référence

Hojjat-Farsangi, Jeddi-Tehrani, Daneshmanesh, Mozaffari, Moshfegh, Hansson, Razavi, Sharifian, Rabbani, Österborg, Mellstedt, Shokri: "Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia." dans: PLoS ONE, Vol. 10, Issue 11, pp. e0142310, (2015) (PubMed).

Détail du antigène

Antigène: ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1))

Autre désignation: Ror1 (ROR1 Produits)

Synonymes: NTRKR1 Protein, dJ537F10.1 Protein, 2810404D04Rik Protein, Ntrkr1 Protein, mRor1 Protein, RGD1559469 Protein, ROR1 Protein, fi34e02 Protein, si:dkey-209n16.1 Protein, wu:fi34e02 Protein, receptor tyrosine kinase like orphan receptor 1 Protein, receptor tyrosine kinase-like orphan receptor 1 Protein, ROR1 Protein, Ror1 Protein, ror1 Protein

Sujet: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 104.1 kDa

NCBI Accession: NP_005003

Pathways: Signalisation RTK, Signalisation WNT, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha