Neuregulin 4 Protein (NRG4) (AA 1-53) (GST tag)
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- Antigène Voir toutes Neuregulin 4 (NRG4) Protéines
- Neuregulin 4 (NRG4)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 1-53
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette Neuregulin 4 protéine est marqué à la GST tag.
- Application
- SDS-PAGE (SDS)
- Réactivité croisée
- Humain
- Attributs du produit
- Human Neuregulin-4 (aa 1-53) is fused at the N-terminus to GST.
- Pureté
- >95 % (SDS-PAGE)
- niveau d'endotoxine
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product NRG4 Protéine
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Neuregulin 4 (NRG4) (AA 1-115) protein (GST tag)
NRG4 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AP, AA
Neuregulin 4 (NRG4) (AA 1-61) protein (His tag)NRG4 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Neuregulin 4 (NRG4) (Active) proteinNRG4 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Neuregulin 4 (NRG4) (AA 1-115) protein (Strep Tag)Crystallography grade NRG4 Origine: Humain Hôte: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Neuregulin 4 (NRG4) (AA 1-115) protein (Strep Tag)Crystallography grade NRG4 Origine: Souris Hôte: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Neuregulin 4 (NRG4) (AA 1-61) protein (rho-1D4 tag)Crystallography grade NRG4 Origine: Humain Hôte: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Neuregulin 4 (NRG4) (AA 1-61) protein (rho-1D4 tag)Crystallography grade NRG4 Origine: Souris Hôte: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Binds to the human receptor tyrosine-protein kinase ErbB4.
- Restrictions
- For Research Use only
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- Format
- Solid
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Date de péremption
- 6 months
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- Antigène
- Neuregulin 4 (NRG4)
- Autre désignation
- Neuregulin-4 (NRG4 Produits)
- Synonymes
- HRG4 Protein, AI552600 Protein, neuregulin 4 Protein, NRG4 Protein, Nrg4 Protein, LOC100347220 Protein
- Sujet
- Neuregulin-4 (Nrg4) belongs to a small family of EGF-like (EGFL) domain-containing proteins that are synthesized as transmembrane precursors and undergo proteolytic cleavage. The EGF-like domain (aa 5-46) of Nrg4 (aa 1-53) directly binds to the receptors ErbB3 and 4. Nrg4 is a cold induced adipokine, highly expressed in adipose tissues and enriched in brown fat. It is increased during brown adipocyte differentiation and reduced in rodent and human obesity. It promotes neurite outgrowth and protects against diet-induced insulin resistance and hepatic steatosis through attenuating hepatic lipogenic signaling. This hepatic effect of Nrg4 is mediated by ErbB3 and ErbB4 signaling that negatively regulates de novo lipogenesis mediated by LXR and SREBP1c. This effect of Nrg4 on fatty liver and insulin resistance could lead to the development of Nrg4 as an effective therapeutic biological for the treatment of NAFLD and type 2 diabetes. GST-Nrg4 (aa 1-53) recombinant protein has been shown to mimic the effect of endogenous secreted Nrg4 on liver lipogenesis.
- Poids moléculaire
- ~32kDa (SDS-PAGE)
- UniProt
- Q8WWG1
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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