P-Selectin Protein (partial) (His tag)

N° du produit ABIN5608410

Détail du produit

Antigène: P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))

Type de proteíne: Recombinant

Attributs du protein: partial

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette P-Selectin protéine est marqué à la His tag.

Application: Western Blotting (WB)

Séquence: Trp 42 - Ala 771

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Endotoxin level is less than 1.0 EU per ug by the LAL method.

Information d'application

Indications d'application: This recombinant protein can be used for WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C,-80 °C

Stockage commentaire: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Détail du antigène

Antigène: P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))

Autre désignation: P-Selectin (SELP Produits)

Synonymes: PSELECT Protein, CD62 Protein, CD62P Protein, GMP140 Protein, GRMP Protein, LECAM3 Protein, PADGEM Protein, PSEL Protein, GMP-140 Protein, Grmp Protein, selectin P Protein, selectin, platelet Protein, Selp Protein, SELP Protein

Sujet: P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in alpha-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

Poids moléculaire: 81.8 kDa

ID gène: 6403

UniProt: P16109