WT1 Protein (AA 147-446, partial) (His tag)

N° du produit ABIN5712782

Détail du produit

Antigène: WT1 (Wilms Tumor 1 (WT1))

Type de proteíne: Recombinant

Attributs du protein: AA 147-446, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette WT1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MEKGYSTVTF DGTPSYGHTP SHHAAQFPNH SFKHEDPMGQ QGSLGEQQYS VPPPVYGCHT PTDSCTGSQA LLLRTPYSSD NLYQMTSQLE CMTWNQMNLG ATLKGVAAGS SSSVKWTEGQ SNHSTGYESD NHTTPILCGA QYRIHTHGVF RGIQDVRRVP GVAPTLVRSA SETSEKRPFM CAYPGCNKRY FKLSHLQMHS RKHTGEKPYQ CDFKDCERRF SRSDQLKRHQ RRHTGVKPFQ CKTCQRKFSR SDHLKTHTRT HTGEKPFSCR WPSCQKKFAR SDELVRHHNM HQRNMTKLQ

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: WT1 (Wilms Tumor 1 (WT1))

Autre désignation: WT1 (WT1 Produits)

Synonymes: AWT1 Protein, EWS-WT1 Protein, GUD Protein, NPHS4 Protein, WAGR Protein, WIT-2 Protein, WT33 Protein, CWT1 Protein, WT1 Protein, XWT1a Protein, wt-1 Protein, wt1 Protein, xWT1 Protein, WT-1 Protein, gud Protein, wagr Protein, wt33 Protein, xwt1 Protein, wit-2 Protein, si:ch211-160j6.3 Protein, zgc:152697 Protein, D630046I19Rik Protein, Wt-1 Protein, XWT1b Protein, XeWT1 Protein, Wilms tumor 1 Protein, Wilms tumor 1 S homeolog Protein, wilms tumor 1b Protein, Wilms tumor protein Protein, Wilms tumor 1 homolog Protein, Wilms tumor 1 L homeolog Protein, WT1 Protein, wt1.S Protein, wt1 Protein, wt1b Protein, Wt1 Protein, wt1.L Protein

Sujet: Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital syst. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

Poids moléculaire: 38.2 kDa

UniProt: P19544

Pathways: Tube Formation