CDK4 Protein (AA 2-303) (His tag)

N° du produit ABIN5712788

Détail du produit

Antigène: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Type de proteíne: Recombinant

Attributs du protein: AA 2-303

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CDK4 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: ATSRYEPVAE IGVGAYGTVY KARDPHSGHF VALKSVRVPN GGGGGGGLPI STVREVALLR RLEAFEHPNV VRLMDVCATS RTDREIKVTL VFEHVDQDLR TYLDKAPPPG LPAETIKDLM RQFLRGLDFL HANCIVHRDL KPENILVTSG GTVKLADFGL ARIYSYQMAL TPVVVTLWYR APEVLLQSTY ATPVDMWSVG CIFAEMFRRK PLFCGNSEAD QLGKIFDLIG LPPEDDWPRD VSLPRGAFPP RGPRPVQSVV PEMEESGAQL LLEMLTFNPH KRISAFRALQ HSYLHKDEGN PE

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Autre désignation: CDK4 (CDK4 Produits)

Synonymes: zgc:153726 Protein, CMM3 Protein, PSK-J3 Protein, Crk3 Protein, 8-6 Protein, CDK4 Protein, CDK4/6 Protein, CG5072 Protein, Cdk4/6 Protein, DmCdk4 Protein, Dmel\\CG5072 Protein, Pk53C Protein, Pk?7 Protein, cdk Protein, cdk4 Protein, cdk4/6 Protein, dCdk4 Protein, l(2)05428 Protein, l(2)0671 Protein, l(2)k06503 Protein, l(2)s4639 Protein, l(2)sh0671 Protein, xcdk4 Protein, cyclin-dependent kinase 4 Protein, cyclin dependent kinase 4 Protein, Cyclin-dependent kinase 4 Protein, cyclin-dependent kinase 4 L homeolog Protein, cdk4 Protein, CDK4 Protein, Cdk4 Protein, cdk4.L Protein

Sujet: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit mbers of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Poids moléculaire: 37.7 kDa

UniProt: P11802

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size