SET/TAF-I Protein (AA 1-290) (His tag)

N° du produit ABIN5853066

Détail du produit

Antigène: SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

Type de proteíne: Recombinant

Attributs du protein: AA 1-290

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SET/TAF-I protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMAPKRQS PLPPQKKKPR PPPALGPEET SASAGLPKKG EKEQQEAIEH IDEVQNEIDR LNEQASEEIL KVEQKYNKLR QPFFQKRSEL IAKIPNFWVT TFVNHPQVSA LLGEEDEEAL HYLTRVEVTE FEDIKSGYRI DFYFDENPYF ENKVLSKEFH LNESGDPSSK STEIKWKSGK DLTKRSSQTQ NKASRKRQHE EPESFFTWFT DHSDAGADEL GEVIKDDIWP NPLQYYLVPD MDDEEGEGEE DDDDDEEEEG LEDIDEEGDE DEGEEDEDDD EGEEGEEDEG EDD

Pureté: > 90 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 20 % glycerol, 1  mM DTT.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

Autre désignation: SET (SET Produits)

Synonymes: 2PP2A Protein, I2PP2A Protein, IGAAD Protein, IPP2A2 Protein, PHAPII Protein, TAF-I Protein, TAF-IBETA Protein, 2610030F17Rik Protein, 5730420M11Rik Protein, AA407739 Protein, I-2PP2A Protein, StF-IT-1 Protein, 2pp2a Protein, i2pp2a Protein, igaad Protein, ipp2a2 Protein, phapii Protein, set Protein, set-a Protein, set-b Protein, taf-ibeta Protein, wu:fb30g11 Protein, wu:fd16c08 Protein, SET nuclear proto-oncogene Protein, SET nuclear oncogene Protein, SET translocation Protein, SET nuclear proto-oncogene L homeolog Protein, SET nuclear proto-oncogene b Protein, SET Protein, Set Protein, LOC403555 Protein, set.L Protein, setb Protein

Sujet: SET inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. Recombinant human SET protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 35.9 kDa (313aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)

NCBI Accession: NP_001116293

UniProt: Q01105

Pathways: Apoptose