CAMLG Protein (AA 1-189) (His tag)

N° du produit ABIN5853110

Détail du produit

Antigène: CAMLG (Calcium Modulating Ligand (CAMLG))

Type de proteíne: Recombinant

Attributs du protein: AA 1-189

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CAMLG protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSMESMAVA TDGGERPGVP AGSGLSASQR RAELRRRKLL MNSEQRINRI MGFHRPGSGA EEESQTKSKQ QDSDKLNSLS VPSVSKRVVL GDSVSTGTTD QQGGVAEVKG TQLGDKLDSF IKPPECSSDV NLELRQRNRG DLTADSVQRG SRHGLEQYLS RFEEAMKLRK QLISEKPSQE DGNTTEEFDS FR

Pureté: > 85 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: CAMLG (Calcium Modulating Ligand (CAMLG))

Autre désignation: CAMLG (CAMLG Produits)

Synonymes: MGC53900 Protein, CAML Protein, AI385748 Protein, Camlg Protein, Caml Protein, calcium modulating ligand L homeolog Protein, calcium modulating ligand Protein, camlg.L Protein, CAMLG Protein, camlg Protein, Caml Protein, Camlg Protein

Sujet: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. Recombinant human CAMLG protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 23.2 kDa (212aa), confirmed by MALDI-TOF

NCBI Accession: NP_001736

UniProt: P49069

Pathways: EGFR Signaling Pathway