Bestrophin 1 Protein (BEST1) (AA 292-585) (His tag)

N° du produit ABIN5853599

Détail du produit

Antigène: Bestrophin 1 (BEST1)

Type de proteíne: Recombinant

Attributs du protein: AA 292-585

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Bestrophin 1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MGSEQLINPF GEDDDDFETN WIVDRNLQVS LLAVDEMHQD LPRMEPDMYW NKPEPQPPYT AASAQFRRAS FMGSTFNISL NKEEMEFQPN QEDEEDAHAG IIGRFLGLQS HDHHPPRANS RTKLLWPKRE SLLHEGLPKN HKAAKQNVRG QEDNKAWKLK AVDAFKSAPL YQRPGYYSAP QTPLSPTPMF FPLEPSAPSK LHSVTGIDTK DKSLKTVSSG AKKSFELLSE SDGALMEHPE VSQVRRKTVE FNLTDMPEIP ENHLKEPLEQ SPTNIHTTLK DHMDPYWALE NRDEAHS

Pureté: > 90 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Denatured

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M urea, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: Bestrophin 1 (BEST1)

Autre désignation: BEST1 (BEST1 Produits)

Synonymes: CG6264 Protein, Dbest Protein, Dmel\\CG6264 Protein, anon-WO0118547.380 Protein, best Protein, dBest1 Protein, dbest1 Protein, dmBest1 Protein, BEST1 Protein, VMD2 Protein, best-1 Protein, ARB Protein, BEST Protein, BMD Protein, RP50 Protein, TU15B Protein, Bmd Protein, Vmd2 Protein, mBest1 Protein, Bestrophin 1 Protein, bestrophin 1 Protein, Best1 Protein, BEST1 Protein, best1 Protein, Bm1_25500 Protein

Sujet: BEST1 is a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Recombinant human BEST1 protein, fused to His-tag at N-terminus, was expressed in E.coli

Poids moléculaire: 36 kDa (317aa)

NCBI Accession: NP_004174

UniProt: O76090