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BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-329) protein (His tag)

BABAM1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
N° du produit ABIN5853835
  • Antigène Voir toutes BRISC and BRCA1 A Complex Member 1 (BABAM1) Protéines
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Type de proteíne
    Recombinant
    Attributs du protein
    AA 1-329
    Origine
    • 5
    • 1
    • 1
    • 1
    • 1
    Humain
    Source
    • 3
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification/Conjugué
    His tag
    Application
    SDS-PAGE (SDS)
    Séquence
    MGSSHHHHHH SSGLVPRGSH MGSMEVAEPS SPTEEEEEEE EHSAEPRPRT RSNPEGAEDR AVGAQASVGS RSEGEGEAAS ADDGSLNTSG AGPKSWQVPP PAPEVQIRTP RVNCPEKVII CLDLSEEMSL PKLESFNGSK TNALNVSQKM IEMFVRTKHK IDKSHEFALV VVNDDTAWLS GLTSDPRELC SCLYDLETAS CSTFNLEGLF SLIQQKTELP VTENVQTIPP PYVVRTILVY SRPPCQPQFS LTEPMKKMFQ CPYFFFDVVY IHNGTEEKEE EMSWKDMFAF MGSLDTKGTS YKYEVALAGP ALELHNCMAK LLAHPLQRPC QSHASYSLLE EEDEAIEVEA TV
    Pureté
    > 85 % by SDS - PAGE
    Top Product
    Discover our top product BABAM1 Protéine
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Liquid. 20  mM Tris-HCl buffer (  pH 8.0) containing 10 % glycerol, 0.1M NaCl
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Antigène
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Autre désignation
    BABAM1 (BABAM1 Produits)
    Synonymes
    merit40 Protein, nba1 Protein, zgc:100909 Protein, c19orf62 Protein, C19orf62 Protein, MERIT40 Protein, NBA1 Protein, C7H19orf62 Protein, 5430437P03Rik Protein, Merit40 Protein, BRISC and BRCA1 A complex member 1 Protein, BRISC and BRCA1 A complex member 1 L homeolog Protein, babam1 Protein, BABAM1 Protein, babam1.L Protein, Babam1 Protein
    Sujet
    BABAM1 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Recombinant human BABAM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
    Poids moléculaire
    38.9 kDa(352aa) confirmed by MALDI-TOF
    NCBI Accession
    NP_001028721
    UniProt
    Q9NWV8
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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