IL12RB1 Protein (AA 24-545) (His tag)
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- Antigène Voir toutes IL12RB1 Protéines
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 24-545
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Origine
- Humain
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Source
- Baculovirus infected Insect Cells
- Purification/Conjugué
- Cette IL12RB1 protéine est marqué à la His tag.
- Application
- SDS-PAGE (SDS)
- Séquence
- CRTSECCFQD PPYPDADSGS ASGPRDLRCY RISSDRYECS WQYEGPTAGV SHFLRCCLSS GRCCYFAAGS ATRLQFSDQA GVSVLYTVTL WVESWARNQT EKSPEVTLQL YNSVKYEPPL GDIKVSKLAG QLRMEWETPD NQVGAEVQFR HRTPSSPWKL GDCGPQDDDT ESCLCPLEMN VAQEFQLRRR QLGSQGSSWS KWSSPVCVPP ENPPQPQVRF SVEQLGQDGR RRLTLKEQPT QLELPEGCQG LAPGTEVTYR LQLHMLSCPC KAKATRTLHL GKMPYLSGAA YNVAVISSNQ FGPGLNQTWH IPADTHTEPV ALNISVGTNG TTMYWPARAQ SMTYCIEWQP VGQDGGLATC SLTAPQDPDP AGMATYSWSR ESGAMGQEKC YYITIFASAH PEKLTLWSTV LSTYHFGGNA SAAGTPHHVS VKNHSLDSVS VDWAPSLLST CPGVLKEYVV RCRDEDSKQV SEHPVQPTET QVTLSGLRAG VAYTVQVRAD TAWLRGVWSQ PQRFSIEVQV SDHHHHHH
- Pureté
- > 85 % by SDS - PAGE.
- niveau d'endotoxine
- < 1.0 EU per 1 microgram of protein (determined by LAL method)
- Top Product
- Discover our top product IL12RB1 Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In phosphate buffered saline ( pH 7.4) containing 30 % glycerol, 1 mM EDTA, 0.1 mM PMSF.
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Antigène
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- Autre désignation
- IL12RB1 (IL12RB1 Produits)
- Synonymes
- Il12rb Protein, IL12RB1 Protein, IL-12R Protein, CD212 Protein, IL-12R-BETA1 Protein, IL12RB Protein, IL-12R[b] Protein, interleukin 12 receptor subunit beta 1 Protein, interleukin 12 receptor, beta 1 Protein, Il12rb1 Protein, IL12RB1 Protein
- Sujet
- IL12RB1, also known as Interleukin-12 receptor subunit beta-1, is a intercellular adhesion molecule 1. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. It forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this protein and IL12RB2 was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Recombinant human IL12RB1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
- Poids moléculaire
- 58.4kDa (528aa) 50-70kDa (SDS-PAGE under reducing conditions.)
- NCBI Accession
- NP_005526
- UniProt
- P42701
- Pathways
- Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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