Integrin beta 2 Protein (ITGB2) (AA 23-700) (His tag)

N° du produit ABIN5854581

Détail du produit

Antigène: Integrin beta 2 (ITGB2)

Type de proteíne: Recombinant

Attributs du protein: AA 23-700

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette Integrin beta 2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: QECTKFKVSS CRECIESGPG CTWCQKLNFT GPGDPDSIRC DTRPQLLMRG CAADDIMDPT SLAETQEDHN GGQKQLSPQK VTLYLRPGQA AAFNVTFRRA KGYPIDLYYL MDLSYSMLDD LRNVKKLGGD LLRALNEITE SGRIGFGSFV DKTVLPFVNT HPDKLRNPCP NKEKECQPPF AFRHVLKLTN NSNQFQTEVG KQLISGNLDA PEGGLDAMMQ VAACPEEIGW RNVTRLLVFA TDDGFHFAGD GKLGAILTPN DGRCHLEDNL YKRSNEFDYP SVGQLAHKLA ENNIQPIFAV TSRMVKTYEK LTEIIPKSAV GELSEDSSNV VQLIKNAYNK LSSRVFLDHN ALPDTLKVTY DSFCSNGVTH RNQPRGDCDG VQINVPITFQ VKVTATECIQ EQSFVIRALG FTDIVTVQVL PQCECRCRDQ SRDRSLCHGK GFLECGICRC DTGYIGKNCE CQTQGRSSQE LEGSCRKDNN SIICSGLGDC VCGQCLCHTS DVPGKLIYGQ YCECDTINCE RYNGQVCGGP GRGLCFCGKC RCHPGFEGSA CQCERTTEGC LNPRRVECSG RGRCRCNVCE CHSGYQLPLC QECPGCPSPC GKYISCAECL KFEKGPFGKN CSAACPGLQL SNNPVKGRTC KERDSEGCWV AYTLEQQDGM DRYLIYVDES RECVAGPNLE HHHHHH

Pureté: > 85 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1 microgram of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: Integrin beta 2 (ITGB2)

Autre désignation: ITGB2 (ITGB2 Produits)

Synonymes: CD18 Protein, LAD Protein, LCAMB Protein, LFA-1 Protein, MAC-1 Protein, MF17 Protein, MFI7 Protein, 2E6 Protein, AI528527 Protein, Cd18 Protein, Lfa1 Protein, ITGB2 Protein, itgb2 Protein, itgb2-a Protein, itgb2-b Protein, integrin subunit beta 2 Protein, integrin beta 2 Protein, integrin subunit beta 2 S homeolog Protein, ITGB2 Protein, Itgb2 Protein, itgb2.S Protein

Sujet: ITGB2, also known as integrin beta-2, is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It may belong to an extended family of cell surface molecules including the fibronectin binding protein. Also It is a complement receptor type 3 (CR3). It triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Recombinant human ITGB2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 75.9kDa (686aa) 70-100kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_000202

Pathways: Signalisation NF-kappaB, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation